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Data & Biorepository

The focus of the Population & Data Sciences Core is to provide expertise for organizing cohorts of individuals with clinical and epidemiologic data as well as biospecimens; this will include support of studies of disease pathogenesis using advanced statistical and data sciences activities.

The Population & Data Sciences Core can provide access to cross-sectional and longitudinal clinical data and biospecimens from informative populations that include:

• Individuals with clinical diagnoses of rheumatoid arthritis (RA). Subgroups include:

             - Seropositive RA, defined as anti-CCP and/or rheumatoid factor positive disease

             - Seronegative RA, defined as anti-CCP and rheumatoid factor negative

             - Early RA, defined as data and materials obtained from within 6 months of initial diagnosis of RA (some                          subjects are within days of diagnosis and have not used DMARDS).

             - Longstanding RA

• Individuals who are at-risk for future RA. Subgroups include:

             - Anti-CCP+ individuals without clinical RA at baseline, some of whom later develop clinical RA

             - First-degree relatives of patients with RA (these FDRs may or may not have anti-CCP or rheumatoid                               factor positivity.

• Autoantibody negative controls without RA
• Inflammatory bowel disease (limited sample set)

Clinical, biomarker and biospecimens that can be available are as follows:

Clinical data:

Demographic features and environmental exposures (e.g. tobacco use, dietary intake), medical history and medication use, participant-reported joint symptoms, physician joint count (66/68), calculated disease activity measures, time-to-event (diagnosis of clinical RA or duration of follow-up).

Biomarker data:

• Levels of anti-CCP, rheumatoid factor, C-reactive protein using clinical-grade assays (each time point)
• HLA DRB1 shared epitope
• Subset with fine specificities of anti-citrullinated protein antibodies 

Biospecimens:

Serum, plasma (EDTA and heparin), DNA (buffy coat), single PAXgene tube (whole blood RNA), PBMCs (in some cases), sputum, stool and urine.

The data and samples that the Population & Data Sciences Core have available is evolving. Please contact us to discuss your needs and learn what is currently available. Please also see the Service and Pricing list below.

The data and biorepository core offers a host of services, described below.  We do an hour free consultation anytime you are interested in discussing our services and your needs, so please reach out to PDS.Core@cuanschutz.edu to discuss further.  

Services and Pricing for the PDS Core

Questions about accessing data, samples or our services, please contact:  PDS.Core@cuanschutz.edu